It depends what you want from it I suppose. Vancouver was a fabulous city when I was there decades ago - the kind of place I think I might like to live now - City, Sea, Mountains, Weather - it has it all. Full of Canucks obviously, but hey, nothing is perfect
Touristy cities - as someone said, Rome is very impressive. Food, History, quite friendly natives, euros, it's sooo easy...
Party City (micro-city really) - Galway, Ireland. What a gem.
Places I didn't like: Lerwick, Shetland.
Mrs willk wants to go to Paris, I'm fighting the idea - who needs to go to an overpriced city full of French people who appear to want you dead? I haven't returned to the USA after the whole security thing got into fingerprinting and body scans and background checks and so forth. Sorry guys, it's a big planet and I can be made feel that unwelcome in Egypt for a fraction of the cost.
Well, that's not an exhaustive list, but it's probably more than you wanted to hear