to be honest, the only time I used petroleum diesel was during the engine break-in period, and once I experienced biodiesel have never had a good reason to use petroleum again...so I have little experience for comparison.
but I can say that biodiesel doesn't smoke, doesn't stink, doesn't burn quicker, and doesn't harm the engine. And when it's spilled on something, like your hands, it's easy on the skin...cleaning any surface rather than contaminating it. There are some things you need to think about though; such as being ready to change fuel filters when you begin using it, because it will act as a solvent and "clean" your tanks. Also, it cannot be used around rubber or some other materials (especially fuel lines). It will gell at a lower temperature so must be treated in cold weather. And be sure your source is relaible in terms of quality'
The biggest downside has been the high cost...but current petroleum prices are making it more competitive and available.
To say it simply, I've had zero problems directly linked to using 100% biodiesel over 35,000 miles and would recommend it without hesitation.